Do not use this product if you are pregnant, breast-feeding, or have scleroderma. Consult a health care practitioner prior to use if you are taking medications for seizure, blood pressure, immune suppression, to affect mental state, increase sedation, steroids, blood thinners, carbidopa, or drugs / supplements with serotonergic activity. These may include, but are not limited to, L-tryptophan, Sadenosylmethionine (SAMe), St. John's wort, antidepressants, pain killers, over the counter cough and cold medication containing dextromethorphan, anti-nausea medication and anti-migraine medication.

Consult a health care practitioner prior to use if you have cardiovascular, immune, liver or chronic kidney disease, hormonal or seizure disorder, asthma, depression, diabetes, low blood sugar, or migraines. Consult a health care practitioner if symptoms persist or worsen. Stop use and consult a health care practitioner if you show signs of weakness, oral ulcers, abdominal pain accompanied by severe muscle pain, or if you experience skin changes. Stop use and consult a health care practitioner if you experience any of the following symptoms within a few hours after taking this product: changes in mental state such as restlessness or confusion, increased heart rate, enlarged pupils, loss of muscle coordination, headache, sweating, shivering, allergy, or gastrointestinal problems such as nausea, vomiting, or diarrhea.

Some people may experience drowsiness. Exercise caution if operating heavy machinery, driving a motor vehicle or involved in activities that require mental alertness. Some people may experience diarrhea, vomiting, and abdominal pain.

Consult a health care practitioner prior to use if you have had recent surgery or have upcoming surgery. Keep out of reach of children.